Drug conjugation is a crucial method used in pharmaceutical research and development to enhance the pharmacokinetic and pharmacodynamic properties of a drug. By attaching various molecules to the drug (antibody conjugation, PEGylation, oligonucleotide bioconjugation, etc.), researchers can improve its solubility, stability, targeting ability, and overall therapeutic efficacy. There...
Introduction
The evaluation of permeability is a crucial aspect of drug discovery and development. It provides insights into how well a compound can cross biological membranes, which significantly influences its bioavailability and therapeutic efficacy. One of the most widely utilized techniques for assessing permeability is the Parallel Artificial Membrane Permeability Assay (PAMPA). This in...
In recent years, the growing concerns over plastic pollution and its detrimental impact on the environment have driven researchers and innovators to seek sustainable alternatives. This push for eco-friendly solutions has led to the development of various degradation technologies aimed at enhancing the breakdown of plastics in a more environmentally responsible manner. Notably, four significant...
Curcumin, a natural compound found in turmeric, has gained attention for its potential health benefits, including anti-inflammatory and antioxidant properties. It has been studied for its ability to support joint health, improve brain function, and reduce the risk of various diseases. However, curcumin's bioavailability – the degree to which it is absorbed and utilized by the body –...
Peptides, including antimicrobial peptides, can be synthesized through various techniques, primarily chemical synthesis and recombinant DNA technology.
Solid-Phase Peptide Synthesis (SPPS)
Solid-phase peptide Synthesis is the most commonly used method for chemical peptide production. This technique, pioneered by R. Bruce Merrifield, involves the stepwise addition of amino acids to a growing...
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