Gemini Smith

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2025-02-19 05:49:26 -

Exploring the Frontiers of COVID-19 Prevention and Treatment
The global battle against the COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has tested the limits of global public health. Across the globe, scientists and researchers have displayed unwavering dedication, resulting in remarkable progress in various realms of COVID-19 research and treatment. This blog post will delve into three pivotal areas of study: the optimization of...

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2024-12-19 08:30:11 -

Advancements in Protein Therapeutics: Extending Half-Life for Improved Efficacy
Macromolecular proteins and peptides have proven to be highly effective in treating serious human diseases. Over the past few decades, advancements in biotechnology have led to the development of numerous authorized protein therapeutics and drug products, which are now widely used in clinical research. However, a major challenge for protein therapeutics remains their short half-lives, primarily...

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2024-12-19 08:24:57 -

Understanding Ribosomal Dysfunction through Advanced Analysis Techniques
Within the intricate microcosm of human cells, comparable to a sophisticated symphony orchestra, ribosomes assume the role of conductors, finely coordinating the synthesis of proteins—the fundamental building blocks of life. Yet, disturbances in ribosomal function intricately connect with cellular dysfunction, playing a significant role in the initiation and progression of diverse...

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2024-12-19 08:05:45 -

ADCC/CDC Enhancement in Therapeutic Antibody Development
Therapeutic antibodies, developed through advanced biotechnology, represent a specialized category of antibodies designed to treat a range of diseases by targeting specific biomarkers. These engineered antibodies are crafted to address malignancies, autoimmune disorders, and infections with greater precision and reduced side effects compared to conventional therapies. In immunotherapy,...

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2024-12-19 07:56:03 -

Pharmaceutical Giants Rush to Develop PD-(L)1 Bispecific Antibodies: A New Battlefield in Immunotherapy
In recent years, immune checkpoint inhibitors (ICIs) have emerged as a significant breakthrough in cancer therapy, reshaping traditional treatment paradigms. PD-1/PD-L1 pathway inhibitors have been widely used across various cancer treatments, demonstrating impressive efficacy. As PD-(L)1 inhibitor therapies continue to mature, pharmaceutical giants have turned their attention to PD-(L)1...

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2024-11-07 07:17:49 -

The Role of AI in Transforming Antibody Validation and Drug Molecule Optimization
The advent of AI technology has revolutionized several sectors, one of which is drug development and validation. The potential of AI technology in informing the processes such as the development of antibodies and optimizing molecules is progressively substantial. AI technology has made it easier, faster, and more accurate to train models, validate antibodies, and optimize molecules for drug...

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2024-11-07 07:10:30 -

How Probiotics Can Transform Health: From Gut Balance to Disease Management
Probiotic strains, the beneficial microorganisms celebrated for their health-promoting properties, are gaining growing recognition in the field of disease treatment. These tiny yet mighty organisms help restore balance to the gut microbiome, a crucial factor in maintaining overall well-being. By promoting gut health, probiotics aid digestion, strengthen immune function, and provide relief from...

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2024-11-07 06:59:46 -

AMG 133 Shows Promise in Obesity Treatment with Dual Action on GIPR and GLP-1 Receptors
Obesity is a heterogeneous chronic disease that has become an extremely prevalent public health problem and one of the greatest threats to human health and well-being in the 21st century. Obesity-related complications place an enormous burden on patients and healthcare systems worldwide, and there is an urgent need for effective and safe obesity treatments. Enteric insulin-based drugs...

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2024-11-07 06:52:23 -

Combination of AMT-253 and Bevacizumab Enhances Tumor Suppression in Melanoma
The advent of BRAF inhibitors and immune checkpoint inhibitors (ICIs) has significantly improved the prognosis of melanoma patients. However, melanoma subtypes such as limbal, mucosal, and uveal melanomas are less responsive to these therapies than cutaneous melanomas, and new therapeutic agents are urgently needed for treatment-resistant patients. Antibody-drug conjugates (ADCs) achieve...

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2024-11-07 06:47:11 -

Macrophages as Biomarkers of Non-Alcoholic Fatty Liver Disease Progression
Non-alcoholic fatty liver disease (NAFLD), as its name indicated, is a condition caused by abnormal or excessive fat buildup in liver, which is not a result of heavy alcohol use. It has become a common chronic liver disease and is affecting up to 25% of people worldwide. Most people have no symptoms, and 2% to 5% of people will experience complications from the fat in their...

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