Linaclotide (CAS 851199-59-2): Mechanism, Clinical Efficacy, and...

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2026-05-22 08:11:23 -

Linaclotide (CAS 851199-59-2): Mechanism, Clinical Efficacy, and Chemical Profile in GI Therapeutics

Linaclotide (CAS 851199-59-2) is a synthetic peptide comprised of 14 amino acids and characterized by three strategically positioned disulfide bonds, giving it a cyclic and conformationally constrained structure. As a highly potent and selective agonist of the guanylate cyclase-C (GC-C) receptor, linaclotide mimics the physiological action of endogenous peptides such as guanylin and...

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