How Long Does It Take for Azithromycin to Work? Azithromycin typically begins working within 24 to 48 hours after the first dose. Most people start noticing symptom relief—such as reduced fever, sore throat, or improved breathing—within 2 to 3 days. However, it's important to complete the entire prescribed course, even if you feel better early, to fully eliminate the infection and prevent antibiotic resistance. The full effect may take up to 5 days, especially for conditions like sinusitis or bronchitis. If symptoms persist or worsen after 3 days, consult your healthcare provider for reassessment. https://www.dosepharmacy.com/azee-500mg-tablet