Profacgen, a leading provider of protein services, announces its comprehensive ternary complex formation service supported by a wide range of cutting-edge techniques. This service enables researchers to effectively evaluate the formation of target-PROTAC-E3 ligase ternary complexes, a crucial step in the development of Proteolysis-Targeting Chimeras (PROTACs) as novel therapeutic agents.

PROTACs represent a revolutionary paradigm in drug discovery, harnessing the cell's own protein degradation machinery to selectively eliminate targeted proteins. The efficacy of PROTACs relies on their ability to form ternary complexes with the target protein and an E3 ubiquitin ligase, leading to the ubiquitination and subsequent proteasomal degradation of the target protein.

Profacgen's ternary complex formation service utilizes a variety of highly sensitive and orthogonal techniques, including Surface Plasmon Resonance (SPR), Bio-Layer Interferometry (BLI), Co-Immunoprecipitation (Co-IP), Nuclear Magnetic Resonance (NMR), Isothermal Titration Calorimetry (ITC), Dynamic Light Scattering (DLS), Fluorescence Polarization (FP), X-ray Crystallography, Fluorescence Resonance Energy Transfer (FRET), and Bioluminescence Resonance Energy Transfer (BRET). These techniques provide a comprehensive understanding of ternary complex formation, from the initial binding interactions to the structural characterization of the complex.

The company's experienced team of scientists works closely with clients to design customized experimental strategies tailored to their specific PROTAC molecules and research objectives. Profacgen's advanced technology platforms and rigorous quality control measures ensure the delivery of accurate, reproducible data with rapid turnaround times.

As a state-of-the-art protein service provider, Profacgen is committed to supporting clients from target identification to drug development. In addition to ternary complex formation analysis, the company offers a range of integrated services, including PROTAC design, synthesis, and in vitro evaluation, as well as protein expression, purification, and interaction analysis.

"Profacgen is dedicated to empowering researchers in the PROTAC field with our cutting-edge ternary complex formation service," said Crystal, the chief marketing staff at Profacgen. "Our expertise and comprehensive approach enable clients to optimize their PROTAC molecules and accelerate their drug development programs."

For more information about Profacgen's ternary complex formation service and other offerings, please visit https://www.profacgen.com/ternary-complex-formation.htm.

About Profacgen

Profacgen is a leading protein service provider located in NY, USA. The company offers a wide range of custom protein services, from protein expression and purification to protein interaction analysis and PROTAC development. Profacgen is committed to delivering high-quality data and exceptional customer service to support its clients in the biopharmaceutical industry and academia.